Phenylboronic acid MIDA ester

Phenylboronic acid MIDA ester - Names and Identifiers

Name	6-Methyl-2-phenyl-1,3,6,2-dioxazaborocane-4,8-dione
Synonyms	Phenylboronic acid MIDA ester 6-Methyl-2-phenyl-1,3,6,2-dioxazaborocane-4,8-dione 2-Phenyl-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
CAS	109737-57-7

Phenylboronic acid MIDA ester - Physico-chemical Properties

Molecular Formula	C11H12BNO4
Molar Mass	233.02828
Melting Point	166-170 °C
Storage Condition	Room Temprature
Use	The use does not contain a crystallization solvent. DMSO may be present up to 10% (mass fraction).

Phenylboronic acid MIDA ester - Risk and Safety

Hazard Symbols	T - Toxic
Risk Codes	25 - Toxic if swallowed
Safety Description	45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3

Phenylboronic acid MIDA ester - Introduction

Phenylboronic acid methyl iminodiacetate is an organic compound with the chemical formula C13H18BNO4. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Phenylboronic acid methyliminodiacetate is a colorless to light yellow liquid.
-Solubility: It is easily soluble in organic solvents, such as ethanol and dimethylformamide.
-Stability: The compound is relatively stable at room temperature.

Use:
-Chemical synthesis: Phenylboronic acid methyl iminodiacetate can be used as an intermediate in organic synthesis. It can undergo transesterification reactions to produce other organic compounds.
-Pharmaceutical field: The compound plays an important role in the synthesis of certain drugs, such as the synthesis of certain anti-cancer drugs.

Preparation Method:
A common synthesis method is to synthesize phenylboronic acid methyl iminodiacetic acid ester by ester exchange reaction of imine. Specific synthesis steps include:
1. reaction of methyl p-tolylborate with ethyl nitroso -2-acetamidoacetate to generate imino-2-(p-tolylboronic acid) ethyl acetate.
2. The imino-2-(p-tolylboronic acid) ethyl acetate is reacted with another esterification reagent, such as ethyl bromoacetate or n-butanol, to generate the final product phenylboronic acid methyl iminodiacetate.

Safety Information:
The safety of phenylboronic acid methyl iminodiacetate needs further evaluation. Because it is an organic compound, it may cause irritation to the skin, eyes and respiratory system when exposed. Always wear appropriate personal protective equipment such as goggles, gloves and respirators when using or handling. Need to pay attention to sealed storage, avoid contact with oxygen or strong oxidant. In case of any accident, seek medical help immediately.

Last Update：2024-04-09 21:04:16